I think that salaries should be increased the longer you keep a job. If you're in the same profession for 50+ years (which would be the lifespan of the game, I'm assuming), rarely does your salary not increase, at least from what I know. There should be stop spaces (like marriage and buying a house) to increase your salary. Include salary+ tokens to save on making more salary cards.
Marriage should be optional. Currently, you have to get married to continue. There should be plusses and minuses to get married. I'm not sure what, but I'm not the one making the game. I'm just being an asshole. I am glad, however, that gay marriage is allowed in the Game of Life, just because the rules can't tell me I can't pick a blue peg to put in my little car.
There needs to be some kind of provision against having children. Maybe get extra LIFE tiles if you choose to not have kids. Or, get pets instead of kids. Maybe guinea pigs of some sort. I'd rather have a guinea pig in a cage instead of twins in my station wagon.
I think there should be more careers. We're in 2007, people. Where's Computer Programmer or Blogger? (For the record, Bloggers should only be able to get $300 a payday. Take that, hippies.)
The closest thing I can find is this: http://www.gameofreallife.com/ Hey, there's drugs, sex and war. I dig it. Someone buy this for me.